Sorry, I don't mean any of this as a flame post, they are just my observations.
Retrospect version
Multi Server Premium - 15.1.2.100
Windows 7 Pro
UAC off
Retrospect Launcher service on
Automatically launch retrospect on
Always run Retrospect as the specified user (set to the user I always log in with)
no proactive scripts, just scheduled scripts at night
Normally I do open it and leave it running but recently I've needed to reboot for non-retrospect related things (win updates, hardware, etc).